Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC002
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-04 09:34
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/2 caps Madopar HBS a 125mg 2 uvece tbl Requip a 2mg jedna ujutru Older patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 29 individuals with a value less than 0.62 were subsequently diagnosed with PD. That is, 69.05% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.62 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 9, 'TN': 11, 'TP': 33, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 19, 'TN': 10, 'TP': 23, 'FP': 20}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 15, 'TN': 9, 'TP': 27, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 12.872
timePerCircleCoV 0.101911
timePerCircleSlope -0.0201141
meanError 1.01484
tremorFreq 7.71484
tremorRelPower 18.9476
tremorGyroAmpMean 0.0132482
tremorGyroAmpSlope 0.001617
tremorGyroAmpCoV 0.359664
tremorCoordAmpMean 0.0250245
tremorCoordAmpSlope 0.00281148
tremorCoordAmpCoV 0.215715
tremorAccAmpMean 0.0572316
tremorAccAmpSlope 0.00064858
tremorAccAmpCoV 0.0443208
tremorPcRelVar 0.644166
tremorPcX -0.876989
tremorPcY 0.48051

Circle Segment 1

Duration 14.52 s, Accuracy Estimate 0.852 (lower is better)

Circle Segment 2

Duration 12.92 s, Accuracy Estimate 0.968 (lower is better)

Circle Segment 3

Duration 13.6 s, Accuracy Estimate 0.799 (lower is better)

Circle Segment 4

Duration 13.44 s, Accuracy Estimate 0.818 (lower is better)

Circle Segment 5

Duration 12.8 s, Accuracy Estimate 0.91 (lower is better)

Circle Segment 6

Duration 11.6 s, Accuracy Estimate 0.948 (lower is better)

Circle Segment 7

Duration 13.56 s, Accuracy Estimate 0.899 (lower is better)

Circle Segment 8

Duration 14.4 s, Accuracy Estimate 0.786 (lower is better)

Circle Segment 9

Duration 10.84 s, Accuracy Estimate 1.215 (lower is better)

Circle Segment 10

Duration 11.04 s, Accuracy Estimate 1.952 (lower is better)

Spiral

numSpirals 9
timePerSpiralMean 31.8889
timePerSpiralCoV 0.123673
timePerSpiralSlope 0.0372962
meanError 1.46669
tremorFreq 9.76562
tremorRelPower 31.2322
tremorGyroAmpMean 0.0224648
tremorGyroAmpSlope 0.00172218
tremorGyroAmpCoV 0.426008
tremorCoordAmpMean 0.0434962
tremorCoordAmpSlope 0.00145722
tremorCoordAmpCoV 0.344009
tremorAccAmpMean 0.0498353
tremorAccAmpSlope 0.00104951
tremorAccAmpCoV 0.222044
tremorPcRelVar 0.857607
tremorPcX 0.647319
tremorPcY 0.762219

Spiral Segment 1

Duration 28.56 s, Accuracy Estimate 1.346 (lower is better)

Spiral Segment 2

Duration 27.72 s, Accuracy Estimate 1.526 (lower is better)

Spiral Segment 3

Duration 28.04 s, Accuracy Estimate 1.396 (lower is better)

Spiral Segment 4

Duration 32.32 s, Accuracy Estimate 1.363 (lower is better)

Spiral Segment 5

Duration 31.88 s, Accuracy Estimate 1.5 (lower is better)

Spiral Segment 6

Duration 29.72 s, Accuracy Estimate 1.48 (lower is better)

Spiral Segment 7

Duration 33.92 s, Accuracy Estimate 1.51 (lower is better)

Spiral Segment 8

Duration 39.76 s, Accuracy Estimate 1.368 (lower is better)

Spiral Segment 9

Duration 35.08 s, Accuracy Estimate 1.711 (lower is better)

Elel

eDurationMean 0.56425
eDurationStd 0.165752
eDurationStdnorm 0.293757
eDurationMedian 0.5375
eDurationQuartdelta 0.1625
eDurationQuartdeltanorm 0.302326
eDurationKurt 5.69429
eDurationTrenddiff -0.105
eDurationTrendratio 0.821277
eWidthMean 5.5341
eWidthStd 1.83549
eWidthStdnorm 0.33167
eWidthMedian 5.3235
eWidthQuartdelta 1.6965
eWidthQuartdeltanorm 0.318681
eWidthKurt 14.742
eWidthTrenddiff -1.1115
eWidthTrendratio 0.815534
eHeightMean 9.00023
eHeightStd 1.37556
eHeightStdnorm 0.152836
eHeightMedian 9.243
eHeightQuartdelta 1.989
eHeightQuartdeltanorm 0.21519
eHeightKurt 2.10131
eHeightTrenddiff 0.4095
eHeightTrendratio 1.04636
eAspectMean 0.622091
eAspectStd 0.219816
eAspectStdnorm 0.35335
eAspectMedian 0.580128
eAspectQuartdelta 0.175336
eAspectQuartdeltanorm 0.302237
eAspectKurt 18.9129
eAspectTrenddiff -0.125717
eAspectTrendratio 0.813037
eSlantMean 0.158337
eSlantStd 0.246259
eSlantStdnorm 1.55529
eSlantMedian 0.108366
eSlantQuartdelta 0.192409
eSlantQuartdeltanorm 1.77555
eSlantKurt 18.0735
eSlantTrenddiff 0.0438166
eRtopMean 0.757204
eRtopStd 0.107272
eRtopStdnorm 0.141669
eRtopMedian 0.784981
eRtopQuartdelta 0.130735
eRtopQuartdeltanorm 0.166546
eRtopKurt 5.40425
eRtopTrenddiff 0.0576018
eRbotMean 0.536971
eRbotStd 0.196416
eRbotStdnorm 0.365785
eRbotMedian 0.522882
eRbotQuartdelta 0.184263
eRbotQuartdeltanorm 0.352398
eRbotKurt 4.26568
eRbotTrenddiff -0.0323342
eRrightMean 0.853103
eRrightStd 0.098767
eRrightStdnorm 0.115774
eRrightMedian 0.87384
eRrightQuartdelta 0.0810789
eRrightQuartdeltanorm 0.0927846
eRrightKurt 11.1901
eRrightTrenddiff 0.0327386
eRleftMean 0.306505
eRleftStd 0.0868354
eRleftStdnorm 0.283308
eRleftMedian 0.303117
eRleftQuartdelta 0.103908
eRleftQuartdeltanorm 0.342798
eRleftKurt 5.16408
eRleftTrenddiff 0.00667638
lDurationMean 0.8965
lDurationStd 0.256975
lDurationStdnorm 0.286643
lDurationMedian 0.85
lDurationQuartdelta 0.1775
lDurationQuartdeltanorm 0.208824
lDurationKurt 8.55201
lDurationTrenddiff -0.0875
lDurationTrendratio 0.90113
lWidthMean 8.82473
lWidthStd 1.47564
lWidthStdnorm 0.167217
lWidthMedian 8.658
lWidthQuartdelta 2.106
lWidthQuartdeltanorm 0.243243
lWidthKurt 2.41163
lWidthTrenddiff 0.6435
lWidthTrendratio 1.07639
lHeightMean 22.8647
lHeightStd 3.60072
lHeightStdnorm 0.157479
lHeightMedian 22.815
lHeightQuartdelta 4.2705
lHeightQuartdeltanorm 0.187179
lHeightKurt 5.53297
lHeightTrenddiff 1.2285
lHeightTrendratio 1.05512
lAspectMean 0.392407
lAspectStd 0.0738246
lAspectStdnorm 0.188133
lAspectMedian 0.390103
lAspectQuartdelta 0.0995287
lAspectQuartdeltanorm 0.255134
lAspectKurt 6.04323
lAspectTrenddiff -0.00634757
lAspectTrendratio 0.983919
lSlantMean 0.14617
lSlantStd 0.111741
lSlantStdnorm 0.764458
lSlantMedian 0.129512
lSlantQuartdelta 0.179013
lSlantQuartdeltanorm 1.38222
lSlantKurt 2.27082
lSlantTrenddiff 0.0716751
lRtopMean 0.784136
lRtopStd 0.103483
lRtopStdnorm 0.131971
lRtopMedian 0.776881
lRtopQuartdelta 0.195673
lRtopQuartdeltanorm 0.251871
lRtopKurt 1.86358
lRtopTrenddiff 0.036415
lRbotMean 0.431919
lRbotStd 0.165538
lRbotStdnorm 0.383262
lRbotMedian 0.422708
lRbotQuartdelta 0.234845
lRbotQuartdeltanorm 0.555572
lRbotKurt 2.34742
lRbotTrenddiff -0.103558
lRrightMean 0.875663
lRrightStd 0.058098
lRrightStdnorm 0.0663474
lRrightMedian 0.881379
lRrightQuartdelta 0.0966147
lRrightQuartdeltanorm 0.109618
lRrightKurt 1.91093
lRrightTrenddiff -0.00580391
lRleftMean 0.217183
lRleftStd 0.0969925
lRleftStdnorm 0.446595
lRleftMedian 0.198142
lRleftQuartdelta 0.15511
lRleftQuartdeltanorm 0.782822
lRleftKurt 2.38349
lRleftTrenddiff -0.045216

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.982775
sumTouchScores 20.6383
meanMovementTime 0.92125
numTouches 21
undershootPercentage 0
overshootPercentage 0

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.965105
sumTouchScores 14.4766
meanMovementTime 1.27071
numTouches 15
undershootPercentage 0
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 18.384
timePerZigzagCoV 0.10767
timePerZigzagSlope -0.044604
meanError 2.22734
tremorFreq 9.57031
tremorRelPower 22.5827
tremorGyroAmpMean 0.0260427
tremorGyroAmpSlope 0.00789775
tremorGyroAmpCoV 0.462203
tremorCoordAmpMean 0.0581202
tremorCoordAmpSlope 0.00791604
tremorCoordAmpCoV 0.404938
tremorAccAmpMean 0.0516387
tremorAccAmpSlope 0.00806299
tremorAccAmpCoV 0.3865
tremorPcRelVar 0.874497
tremorPcX 0.392568
tremorPcY 0.919723

ZigZag Segment 1

Duration 19.0 s, Accuracy Estimate 2.053 (lower is better)

ZigZag Segment 2

Duration 19.04 s, Accuracy Estimate 2.259 (lower is better)

ZigZag Segment 3

Duration 21.0 s, Accuracy Estimate 2.1 (lower is better)

ZigZag Segment 4

Duration 16.92 s, Accuracy Estimate 2.518 (lower is better)

ZigZag Segment 5

Duration 15.96 s, Accuracy Estimate 2.206 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 16.816
timePerZigzagCoV 0.0367197
timePerZigzagSlope 0.00689819
zigzagHeightMean 61.9851
zigzagHeightCoV 0.0114685
zigzagHeightSlope 0.00389518
meanError 0.0305415
tremorFreq 9.375
tremorRelPower 33.9904
tremorGyroAmpMean 0.038817
tremorGyroAmpSlope 0.000300376
tremorGyroAmpCoV 0.373961
tremorCoordAmpMean 0.0923494
tremorCoordAmpSlope 0.00139673
tremorCoordAmpCoV 0.323358
tremorAccAmpMean 0.0793614
tremorAccAmpSlope 0.00159965
tremorAccAmpCoV 0.34907
tremorPcRelVar 0.911182
tremorPcX -0.477244
tremorPcY -0.878771

ZigZag Offset Segment 1

Duration 16.2 s, Accuracy Estimate 0.055 (lower is better)

ZigZag Offset Segment 2

Duration 17.32 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 3

Duration 16.32 s, Accuracy Estimate 0.016 (lower is better)

ZigZag Offset Segment 4

Duration 17.6 s, Accuracy Estimate 0.02 (lower is better)

ZigZag Offset Segment 5

Duration 16.64 s, Accuracy Estimate 0.037 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.71}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.62}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.635658906114327}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.7527013859597342}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7137867214078727}